2019 GU XIAOCHENG LECTUREThe 2019 GU XIAOCHENG LECTURE is awarded to Dr. Guang-hui Liu of Institute of Zoology，Chinse Academy of Sciences.The Gu Xiaocheng lecture award was established by the Gu Xiaocheng Memorial Fund in 2012. The lectureship recognizes young investigators showing promises to become future leaders inlife science research，especially those who work in China.Dr.Guang-hui Liu received his Ph.D. from Institute of Biophysics，Chinese Academy of Sciences，China in 2007. He did postdoctoral research in The Scripps Research Institute （2007-2009）and Salk Institute for Biological Studies（2009-2012）in USA. Under the National 1000 Young Talents Program，Dr. Liu became a member of Institute of Biophysics，Chinese Academy of Sciences，in 2012. He recently moved his laboratory to Institute of Zoology，Chinese Academy of Sciences.In his study of aging mechanism，Dr. Liufirst discovered that SIRT6 forms a complex with both nuclear factor erythroid2-related factor 2 （NRF2） and RNA polymerase II. This complex could transactivate NRF2-regulated antioxidant genes. This activation may induce overexpression of HO-1 in SIRT6-null human mesenchymal stem cells to rescue premature cellular attrition. Furthermore, a SIRT6-null cynomolgus monkey（Macaca fascicularis）model was created by using a CRISPR-Cas9-based approach.SIRT6 deficiency led to histone hyperacetylation at the imprinting control region ofH19，which results in CTCF recruitment and upregulation of H19. This maysuggest that SIRT6 functions are related to human perinatal lethality syndrome.In another study, Dr. Liu found that DiGeorge syndrome critical region 8（DGCR8） is important in maintaining heterochromatin organization and attenuating aging. Overexpression of DGCR8 alleviated mouse osteoarthritis，which points to a potential drug target for osteoarthtitis.Dr. Liu is recognized for his original contributions to the understanding of molecular mechanisms of stem cell aging,and stem cell based gene therapy. His work is fundamental to the future development of translational medicine for aging related diseases. He has comeon stage as a new leader in the field of aging research.Dr. Liu will present his latest work inthe 11th Ray Wu Symposium at School of Life Sciences，Xiamen University，on November 2, 2019.
2019年顧孝誠講座授予中國科學(xué)院動(dòng)物研究所劉光慧博士。
顧孝誠講座獎(jiǎng)由顧孝誠紀(jì)念基金會(huì)于2012年設(shè)立。該獎(jiǎng)鼓勵(lì)生命科學(xué)研究領(lǐng)域有潛力成為未來學(xué)科領(lǐng)袖的青年科學(xué)家，特別是那些學(xué)成回國的青年學(xué)者。
劉光慧博士于2007年獲得中國科學(xué)院生物物理研究所理學(xué)博士學(xué)位。他曾在美國斯克利普斯（Scripps）研究所（2007-2009）和索爾克（Salk）生物學(xué)研究（2009-2012）從事博士后研究。2012年，劉博士獲得中組部青年千人計(jì)劃支持并就職于中國科學(xué)院生物物理研究所。他最近將實(shí)驗(yàn)室遷到了中國科學(xué)院動(dòng)物研究所。在對衰老機(jī)制的研究中，劉博士首先發(fā)現(xiàn) SIRT6 與核因子紅細(xì)胞2相關(guān)因子2（NRF2）和 RNA 聚合酶II形成復(fù)合物。這種復(fù)合物可以逆轉(zhuǎn) NRF2 調(diào)節(jié)的抗氧化基因。這種激活可能誘導(dǎo) SIRT6 缺失的人骨髓間充質(zhì)干細(xì)胞中 HO-1 的過度表達(dá)，以挽救細(xì)胞的早衰。此外，利用 CRISPR-C9 方法建立了一個(gè) SIRT6 零食蟹猴模型。SIRT6 缺乏導(dǎo)致 H19 印記控制區(qū)組蛋白高乙?；瑢?dǎo)致 CTCF 募集和H19 上調(diào)。這可能提示 SIRT6 功能與圍產(chǎn)兒死亡綜合征有關(guān)。在另一項(xiàng)研究中，劉博士發(fā)現(xiàn) DiGeorge 綜合征臨界區(qū)8（DGCR8）在維持異染色質(zhì)組織和延緩衰老方面有很重要的作用。DGCR8 的過度表達(dá)減輕了小鼠骨關(guān)節(jié)炎，提示了骨關(guān)節(jié)炎的潛在藥物靶點(diǎn)。劉博士在干細(xì)胞衰老的分子機(jī)制研究和干細(xì)胞的基因治療領(lǐng)域做出了重要的原創(chuàng)性研究工作。他的工作對老年相關(guān)疾病轉(zhuǎn)化醫(yī)學(xué)的未來發(fā)展具有重要意義。他已成為老齡化研究領(lǐng)域新的領(lǐng)軍人物。劉博士將于2019年11月2日在廈門大學(xué)生命科學(xué)學(xué)院第十一屆吳瑞紀(jì)念研討會(huì)上介紹他的最新研究成果。制版編輯 | 皮皮魚
